CLINICAL RESEARCH

Outcomes of half-width vertical rectus transposition augmented with posterior fixation sutures for sixth cranial nerve palsy

Ortal Fogel-Tempelhof, Anat Bachar Zipori, Chaim Stolovitch, Oriel Spierer

Various vertical recti transposition procedures have been reported for esotropia due to complete sixth cranial nerve palsy. In this retrospective study the authors describe the experience with half-thickness vertical muscles transposition (VRT) augmented with posterior fixation sutures in 15 patients with sixth nerve palsy. The authors confirmed that half-width VRT with posterior fixation sutures for complete sixth nerve palsy, is a safe procedure with a relatively favorable outcome.

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半宽度垂直直肌移位术结合后部缝线固定治疗第六颅神经麻痹的疗效

已报道有多种垂直直肌移位手术用于治疗由完全性第六颅神经麻痹而引起的内斜视。该回顾性研究中，作者描述了15例第六神经麻痹患者采用半宽度垂直直肌移位术(VRT)结合后部缝线固定治疗的经验。作者证实，半宽度VRT结合后部缝线固定治疗完全性第六神经麻痹是一种安全且预后良好的手术方法。

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CLINICAL RESEARCH

Establishment of a prediction tool for ocular trauma patients with machine learning algorithm

Seungkwon Choi, Jungyul Park, Sungwho Park, Iksoo Byon, Hee-Young Choi

Open globe injury (OGI) is a major cause of permanent visual impairment and blindness. Prediction of the final visual acuity of patients with OGI is essential for patient. Many factors influence the prediction of the final visual acuity, and it is practically difficult to combine and interpret them through conventional statistical methods. Therefore, we applied the machine learning (ML) algorithm to predict the final visual acuity more accurately. The authors performed a retrospective chart review of 190 patients with OGI. Prediction models were built, and the best algorithm was selected to analyze the predicted final visual acuity. To increase the efficiency and efficacy of the prognostic tool, the top 14 features were finally selected using the permutation feature importance method. This tool is useful and easily accessible to doctors and patients, reducing the socioeconomic burden. The authors aim to improve the applicability of this tool, applying the ML technique for patients with various diseases.

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基于机器学习算法的眼外伤患者预测工具的建立

开放性眼球损伤（OGI）是造成永久性视力损害和失明的一个主要原因。OGI患者最终视力的预测对患者来说至关重要。实际上，影响最终视力预测的因素很多，很难通过传统的统计方法对它们进行组合和解释。因此，我们应用机器学习算法来更准确地预测最终视力。作者对190例OGI患者进行了回顾性图表分析,建立预测模型，选取最优算法分析预测最终视力。为了提高预测工具的效率和有效性，最终使用特征重要性排序法选择前14个特征。这一工具非常有用，医生和患者都可以轻松使用，减少了社会经济负担。研究者的目标是提高这个工具的适用性，将机器学习技术应用于多种疾病患者。

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CLINICAL RESEARCH

Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema

Jie Yan, Wu-Jun Li, Ya-Zhou Qin, Xuan-Yu Qiu, Li Qin, Jing-Ming Li

This cross-sectional study aims to quantitatively detect aqueous levels of angiopoietin-like (ANGPTL)3, ANGPTL4, and ANGPTL6 and investigate their correlation with optical coherence tomography angiography (OCTA) findings in patients with diabetic macular edema (DME). This study showed that compared with control subjects, DME patients had higher aqueous ANGPTL4 and ANGPTL6 levels, a lower vessel density, perfusion density, and foveal avascular zone circularity index, and a larger circularity index area and circularity index perimeter. Most importantly, ANGPTL4 and ANGPTL6 levels showed a significant correlation with alterations in OCTA parameters that are indicative of macular edema. These results strongly suggest that ANGPTL4 and ANGPTL6 are associated with vascular leakage in DME and may represent good targets for DME therapy. In addition, OCTA metrics may be useful for evaluating macular ischemia in DME.

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糖尿病性黄斑水肿患者房水血管生成素样蛋白水平与光学相干断层扫描血管造影指标的相关性

该横断面研究旨在定量检测糖尿病黄斑水肿患者血管生成素样蛋白ANGPTL3、ANGPTL4和ANGPTL6的水平，并研究其与OCTA结果的相关性。研究表明，与对照组相比，糖尿病性黄斑水肿患者的房水ANGPTL4和ANGPTL6水平较高，血管密度、灌注密度和中心凹无血管区圆形指数较低，圆形指数的面积和周长较大。并且黄斑水肿患者的ANGPTL4和ANGPTL6水平与OCTA参数的改变显著相关。这些结果明显表明ANGPTL4和ANGPTL6与的血管渗漏有关并可能是糖尿病黄斑水肿治疗的潜在靶点。此外，OCTA参数可能有助于评估患者的黄斑缺血情况。

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META-ANALYSIS

Efficacy and safety of non-penetrating glaucoma surgery with phacoemulsification versus non-penetrating glaucoma surgery: a Meta-Analysis

Jun-Yan Xiao, An-Yi Liang, Yue-Lin Wang, Gang-Wei Cheng, Mei-Fen Zhang

This study compared the clinical efficacy and safety of non-penetrating glaucoma surgery plus phacoemulsification (Phaco-NPGS) and NPGS-alone.The authors systematically searched various databases and reviewed studies that had evaluated the effects of Phaco-NPGS or NPGS-alone for patients with glaucoma. Primary outcomes included postoperative intraocular pressure (IOP) and the number of postoperative antiglaucoma medications. Secondary outcomes were the prevalence of complications, incidence of needling or goniopuncture, and surgical success rate. Phaco-NPGS superior to NPGS-alone in the reduction of IOP and medications. Phaco-NPGS can be recommended for glaucoma patients with coexisting cataracts owing to its superior efficacy, fewer complications, and postoperative procedures.

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非穿透性青光眼手术联合超声乳化术与非穿透性青光眼手术的疗效和安全性比较：Meta分析

该研究比较了非穿透性青光眼手术联合超声乳化术(Phaco-NPGS)和单纯非穿透性青光眼手术(NPGS)的临床疗效和安全性。作者系统地检索了各数据库并回顾了评估Phaco-NPGS或单独NPGS对青光眼患者影响的研究。主要结局包括术后眼压（IOP）和术后抗青光眼药物的数量。次要结局是并发症的发生率、房角穿刺的发生率以及手术成功率。Phaco-NPGS在降低眼压和用药方面均优于NPGS。由于Phaco-NPGS具有更好的疗效，较少的并发症和术后操作，推荐青光眼合并白内障的患者采用。

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