BASIC RESEARCH

Protective limb remote ischemic post-conditioning against high-intraocular-pressure-induced retinal injury in mice

Qi-Jiang Zhu, Lei Zhang, Shuang-Yu Lyu, Zhan-Jun Cui, En-She Jiang, Jun Wang

The study was focused on the effects of remote limb ischemic post-conditioning (LRIC) on high IOP induced retinal injury in mice. The results suggested that LRIC treatment has retinal protective effects against high IOP injury. The endogenous humoral factors released into circulation by LRIC may contribute the protection by reduce the monocytes infiltration and/or microglia activation.

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小鼠肢体远端缺血预处理对高眼压视网膜损伤的保护作用

该研究旨在探索小鼠肢体远端缺血预处理(LRIC)对高眼压视网膜损伤的影响。结果提示LRIC对高眼压损伤有视网膜保护作用。LRIC所致的释放到循环中的内源性体液因子可能通过减少单核细胞浸润和/或小胶质细胞激活发挥保护作用。

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BASIC RESEARCH

CCPG1 involved in corneal Aspergillus fumigatus infection

Li-Mei Wang, Xiao-Meng Chen, Hai-Jing Yan, Shu Yan, Xiao-Yan Sun, Da-Wei Zhang, Hua Yang, Dan-Li Lu, Cheng-Ye Che

This study investigated whether non-canonical autophagy transport receptor cell cycle progression 1 (CCPG1) is involved in the corneal antifungal immune response. The results showed the expression of CCPG1 started to increase at 4h after infection and increased in a time-dependent manner in human corneal epithelial cells (HCECs) and human myeloid leukemia mononuclear cells (THP-1) macrophages. CCPG1 up-regulation in response to Aspergillus fumigatus (A. fumigatus) infection was independent of Dectin-1. Immunofluorescence showed the colocalization of CCPG1 and C-type lectin-like receptor-1 (CLEC-1) in THP-1 macrophages. As a specific autophagy protein of non-canonical autophagy pathway, CCPG1 is involved in corneal infection with A. fumigatus.

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CCPG1参与角膜烟曲霉感染

该研究探讨了自噬受体蛋白CCPG1是否参与角膜抗真菌免疫反应。结果表明CCPG1的表达在感染后4小时开始增加，并且在人角膜上皮细胞（HCECs）和人髓系白血病单核细胞（THP-1）来源巨噬细胞中的表达呈时间依赖性，并且烟曲霉感染后CCPG1的上调与dectin-1无关。免疫荧光显示CCPG1和CLEC-1在THP-1巨噬细胞中共存。作为非经典自噬通路的特异性自噬蛋白，CCPG1参与了烟曲霉角膜感染。

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CLINICAL RESEARCH

Preoperative laser reduces silicone oil use in primary diabetic vitrectomy

Wen-Bin Zheng, Xiao-Hu Ding, Kun-Bei Lai, Ji-Zhu Li,Yu-Qing Wu, Yuan Ma, Zi-Ye Chen, Shi-Da Chen, Sai-Nan Xiao, Bing-Qian Liu, Ying Lin, Tao Li

Due to the aging population and the increasing prevalence of diabetes, the number of people suffering vision-threatening proliferative diabetic retinopathy (PDR) has significantly increased in recent years. Vitrectomy has been established as the ultimate treatment of severe PDR related complications and silicone oil has been used as an effective endotamponade agent that increases the success rate of complicated cases undergoing vitrectomy. In this study, 690 patients (798 eyes) who underwent primary diabetic vitrectomy at a tertiary eye hospital in China from January 2018 to December 2018 were reviewed. The binary logistic regression model was used to evaluate the risk factors for the use of silicone oil as endotamponade agent during primary vitrectomy for PDR-related complications. It turns out that lack of preoperative laser treatment were predictors of silicone oil tamponade during primary vitrectomy for PDR. The results are essential for retinal surgeons when formulating a surgical plan for PDR patients.

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术前激光治疗可减少糖尿病玻璃体切除术中硅油的使用

由于人口老龄化和糖尿病发病率的增加，近年来，威胁视力的增殖性糖尿病视网膜病变(PDR)患者数量显著增加。玻璃体切除术已成为重度PDR相关并发症的基本治疗方法，硅油作为一种有效的眼内填充剂，提高了复杂病例行玻璃体切除术的成功率。该研究回顾了2018年1月至2018年12月在中国一家三级眼科医院接受糖尿病玻璃体切除术的690例患者(798眼)。采用二元logistic回归模型评价在玻璃体切除术中应用硅油作为眼内填充剂治疗PDR相关并发症的危险因素。结果表明，术前缺乏激光治疗是PDR玻璃体切除术中需要进行硅油填充的预测因素。该结果可作为视网膜外科医生为PDR患者制定手术计划的重要参考。

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CLINICAL RESEARCH

One-year outcomes and predictable factors for microhook ab interno trabeculotomy

Daiki Sakai, Masashi Fujihara, Satoshi Yokota, Makoto Nakamura, Yasuo Kurimoto

This study aimed to investigate the factors and short-term outcomes influencing the surgical results of microhook ab interno trabeculotomy (μLOT). This study was conducted based on the limited knowledge on the surgical outcomes of μLOT. The 59 eyes of 59 patients comprising 28 eyes with primary open angle glaucoma and 31 with secondary open angle glaucoma were included and retrospectively reviewed, and the rate of surgical success was evaluated. This study shows that μLOT is a good treatment, predominantly for primary open angle glaucoma.

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Microhook内路小梁切开术一年的疗效和影响手术结果的因素

该研究旨在探讨影响microhook内路小梁切开术手术结果的因素和短期疗效。研究是基于对microhook内路小梁切开术手术结果的有限了解进行的。该回顾性分析纳入59例患者的59只眼，包括28眼原发性开角型青光眼和31眼继发性开角型青光眼并评估了其手术成功率。研究表明microhook内路小梁切开术是一种主要用于原发性开角型青光眼的较好的治疗方法。

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