BASIC RESEARCH

Yes-associated protein promotes endothelial-to-mesenchymal transition of endothelial cells in choroidal neovascularization fibrosis

Rong Zou, Yi-Fan Feng, Ya-Hui Xu, Min-Qian Shen, Xi Zhang, Yuan-Zhi Yuan

This study aimed to clarify the role of Yes-associated protein (YAP) in hypoxia-inducible factor-1α (HIF-1α)-induced endothelial-to-mesenchymal transition (EndMT). It turns that silencing of YAP expression significantly prevented the fibrotic process in a laser-induced choroidal neovascularization (CNV) mouse model, which suggests that YAP may be an attractive target for treatment of age-related macular degeneration (AMD) with the advantage of controlling both CNV and subretinal fibrosis. These findings reveal a critical role of the HIF-1α/YAP signaling axis in EndMT and provide a new therapeutic target for treatment of subretinal fibrosis in AMD.

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Yes相关蛋白在脉络膜新生血管纤维化中促进内皮细胞间充质转化

该研究旨在阐明Yes相关蛋白(YAP)在缺氧诱导因子-1α诱导内皮细胞间充质转化(EndMT)中的作用。结果表明，在激光诱导的脉络膜新生血管(CNV)小鼠模型中，抑制YAP表达可显著阻止纤维化过程。鉴于YAP在CNV和网膜下纤维化方面的优势，可作为年龄相关性黄斑变性(AMD)的值得关注的治疗靶点。该研究揭示了HIF-1α/YAP信号通路在EndMT中的重要作用，为治疗AMD网膜下纤维化提供了新的治疗靶点。

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CLINICAL RESEARCH

Neuroretinal dysfunction in patients affected by neurofibromatosis type 1

Antonietta Moramarco, Luca Lucchino, Fabiana Mallone, Michela Marcelli, Ludovico Alisi, Vincenzo Roberti, Sandra Giustini, Alessandro Lambiase, Marcella Nebbioso

This study aims to examine neuroretinal function by using the multifocal electroretinography (mfERG) test in patients with neurofibromatosis type 1 (NF1) without optic pathway gliomas (OPGs). This study was conducted on 35 patients (35 eyes) with NF1 and 30 healthy subjects (30 eyes) for the control group. The mfERG evaluation in patients affected by NF1 showed a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees attributable to retinal function impairment. This abnormality is subclinical as all patients, did not have a reduced visual acuity nor had any underlying disease that could have affected the outcome of the research. These observations suggest a possible use of mfERG as subclinical retinal damage indicator with a potential utility in clinical practice for the follow-up of NF1 patients.

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1型神经纤维瘤病患者的神经视网膜功能障碍

该研究旨在通过多焦视网膜电图检测无视路胶质瘤的1型神经纤维瘤病患者的神经视网膜功能。该研究纳入了35例（35只眼）1型神经纤维瘤病患者和30例（30只眼）健康受试者作为对照组。1型神经纤维瘤病患者的多焦视网膜电图评估显示，由于视网膜功能受损，2-25度中央视网膜的P1波振幅降低。因为所有患者视力都没有下降且没有任何可能影响研究结果的潜在疾病，所以这种异常为亚临床。多焦视网膜电图可用作亚临床视网膜损伤的指标，在临床实践中对1型神经纤维瘤病患者的随访具有潜在实用价值。

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REVIEW

Inflammation and dry eye disease-where are we?

Srinivas K Rao, Rishi Mohan, Nikhil Gokhale, Himanshu Matalia, Paras Mehta

The presence of inflammation in dry eye disease (DED) results in increased patient symptomatology, ocular surface damage and worsening tear dysfunction. It also affects the health of meibomian glands and their secretions which further aggravates ocular surface disease. This article reviews current knowledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED, inflammation and meibomian gland dysfunction (MGD).

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炎症和干眼症——何去何从？

炎症会导致干眼症（DED）的症状加重、眼表损伤以及泪液功能障碍的加重，还会影响睑板腺及其分泌物的健康，从而进一步加重眼表疾病。该综述回顾了目前DED眼表炎症的研究进展，并探讨了DED、炎症和睑板腺功能障碍（MGD）之间的恶性循环。

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