COMMENTARY

Intraocular lens removal or not during vitrectomy for acute infectious endophthalmitis after cataract surgery

Yan-Nian Hui

At present, the incidence of infectious endophthalmitis after cataract surgery has been significantly reduced, but it is still a serious complication. Removal or not of the intraocular lens (IOL) during vitrectomy in cases with a moderate or severe inflammation is controversial. In order to call upon more attention, we discuss this controversial situation in this issue. With recent advanced vitrectomy techniques, and critical measures for management of risk factors related to occurrence of infection, IOL remaining during timely vitrectomy for acute endophthalmitis can possibly be safe and effective in selected cases.

对照译文

白内障术后急性感染性眼内炎玻璃体切除术中是否摘除人工晶状体

目前，白内障手术后感染性眼内炎的发生率已明显降低，但仍是一种严重的并发症。对于中度或重度炎症患者，玻璃体切除术中是否摘除人工晶状体（IOL）存在争议。为了引起更多的关注，我们在本期对这一争议进行了讨论。随着近年来先进的玻璃体切除技术和与感染发生相关的危险因素管理关键措施的应用，急性眼内炎玻璃体切割术中保留人工晶状体可能在特定的病例中是安全有效的。

PDF Fulltext

BASIC RESEARCH

Evaluation of nintedanib as a new postoperative antiscarring agent in experimental extraocular muscle surgery

Gozde Bicaklioglu, Dilara Pirhan, Yusufhan Yazir, Gokhan Duruksu, Selenay Furat Rencber, Nursen Yuksel

This study aimed to investigate the efficacy of nintedanib on reducing postoperative inflammation, fibrosis and adhesion formation following extraocular muscle surgery in rabbits in comparison with triamcinolone acetonide (TA). It turns that conjunctival and scleral inflammation in TA and nintedanib groups were significantly reduced compared to saline group. Nintedanib appears to attenuate postoperative inflammation and fibrosis after extraocular muscle surgery. But TA showed its main effect as an anti-inflammatory agent, its antifibrotic effect was weaker. Nintedanib may be a safer and stronger alternative agent in extraocular muscle surgery when compared to steroids. Although the researcher think that nintedanib may have a role in improvement of extraocular muscle surgery success, further investigations are needed to determine long term toxic effects and duration, application and dosage of nintedanib treatment.

对照译文

尼达尼布作为一种新型术后抗瘢痕制剂在实验性眼外肌手术中的应用评估

该研究旨在比较尼达尼与曲安奈德(TA)对兔眼外肌手术后炎症、纤维化及粘连形成的影响。结果表明与生理盐水组相比，TA组和尼达尼布组结膜和巩膜的炎症明显减轻。尼达尼布可以减轻眼外肌术后的炎症和纤维化。TA的作用以抗炎为主，抗纤维化作用较弱。与类固醇相比，尼达尼布可能是一种更安全、更强的眼外肌手术替代药物。虽然研究人员认为尼达尼布可能对提高眼肌外手术的成功率有一定作用，但仍需进一步的研究来确定尼达尼布的长期毒性作用和持续时间以及用法与用量。

PDF Fulltext

REVIEW ARTICLE

Etiology, pathogenesis, and diagnosis of neovascular glaucoma

Dan C?lug?ru, Mihai C?lug?ru

Neovascular glaucoma is a secondary glaucoma that is most frequently caused by severe retinal ischemia. The most common diseases responsible for the development of neovascular glaucoma are diabetic retinopathy, ischemic central retinal vein occlusion, and ocular ischemic syndrome. Uncommon causes include ocular radiation, ocular tumors, uveitis and other miscellaneous conditions. Vascular endothelial growth factor is an important and likely predominant protein involved in the pathogenesis of intraocular neovascularization and neovascular glaucoma. The evolution of clinical and histopathological changes from predisposing conditions to the occurrence of rubeosis iridis and neovascular glaucoma is divided into four stages: prerubeosis, preglaucoma, open angle glaucoma, and angle-closure glaucoma.

对照译文

新生血管性青光眼的病因，发病机制和诊断

新生血管性青光眼是一种继发性青光眼，最常见的原因是严重视网膜缺血。导致新生血管性青光眼的最常见疾病是糖尿病视网膜病变、缺血型视网膜中央静脉阻塞和眼缺血综合征。不常见的原因包括眼辐射、眼肿瘤、葡萄膜炎和其他各种疾病。血管内皮生长因子是参与眼内新生血管和新生血管性青光眼发病机制的重要且可能占主导地位的蛋白。从易感因素到虹膜红变和新生血管性青光眼的发生，临床和组织病理学变化的演变分为四个阶段：红变前期、青光眼前期、开角型青光眼和闭角型青光眼。

PDF Fulltext

BRIEF REPORT

Timely vitrectomy without intraocular lens removal for acute endophthalmitis after cataract surgery

Hai-Xia Guo, Ruo-Tian Xie, Yun Wang, Cai-Yun You, Yuan-Yuan Liu, Xiang-Da Meng, Jin-Guo Yu, Hua Yan

Acute post-cataract endophthalmitis remains the most serious complication after cataract surgeries. IOL removal decreased uncorrected and/or best-corrected visual acuity and left the patients unsatisfied with the visual results, which most likely led to postoperative medical dissension during vitrectomy. By now, there are few reports on the effect of vitrectomy for postoperative pseudophakic endophthalmitis without IOL removal, therefore, the clinical feature, causative organism, and effect of vitrectomy and silicone oil tamponade without IOL removal on the treatment of acute-onset endophthalmitis after cataract surgery are reported here using a small case series. In conclusion, under systemic antibiotic treatment and timely diagnosis, vitrectomy and silicone oil tamponade without IOL removal is a safe and effective method for acute-onset endophthalmitis after cataract surgery.

对照译文

白内障术后急性眼内炎应及时行玻璃体切除术而不摘除人工晶状体

急性白内障后眼内炎是白内障手术后最严重的并发症。人工晶状体摘除降低了裸眼视力和/或最佳矫正视力，使患者对视力结果不满意，这很可能导致玻璃体切除术后的医疗纠纷。到目前为止，玻璃体切除术治疗白内障术后眼内炎而不摘除人工晶状体的报道很少，因此，该文通过一个病例系列报道了白内障术后急性发作性眼内炎的临床特点、致病菌以及玻璃体切除联合硅油填充术而不摘除人工晶状体的疗效。在全身抗生素治疗和及时诊断的情况下，玻璃体切除联合硅油填充术并保留人工晶体是治疗白内障术后急性眼内炎安全有效的方法。

PDF Fulltext