BASIC RESEARCH

Effect of light-emitting diodes with different color rendering indexes on the ocular tissues of rat

Wen-Yi Chen, Kun-Hong Xiao, Rong Lin, Ze-Ren Qiu, Ya-Min Chen, Ze-Qun Lin, Xiu-Bin Ke, Yan Huang

This study aims to compare the damage of light-emitting diodes (LEDs) with different color rendering indexes (CRIs) to the ocular surface and retina of rats. Rats were exposed to three LEDs with different CRIs to observe dry eye indicators, lacrimal gland and retinal pathological changes. The protein expression levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the lacrimal gland were assessed via immunofluorescence. The results show that LED exposure for 4wk can cause the pathological changes of lacrimal gland and retina of rats, and increase the expression of TNF-α and IL-6 in lacrimal gland, the degree of damage is negatively correlated with the CRI.

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不同显色指数的发光二极管对大鼠眼组织的影响

该研究旨在比较不同显色指数的发光二极管对大鼠眼表和视网膜的损伤。将大鼠暴露于三种不同显色指数的发光二极管下，观察其干眼指标、泪腺和视网膜病理变化，应用免疫荧光法检测泪腺中肿瘤坏死因子α和白细胞介素6的蛋白表达水平。研究结果表明连续四周暴露于发光二极管可引起大鼠泪腺和视网膜的病理改变，并增强泪腺中肿瘤坏死因子α和白细胞介素6的表达，损伤程度与显色指数呈负相关。

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CLINICAL RESEARCH

Neuromyelitis optica spectrum disorders and anti-myelin oligodendrocyte glycoprotein positive optic neuropathies

Patrick Murtagh, Amy Coman, Kirk Stephenson, Maria Gaughan, David Ryan, Graeme McNeill, Christopher McGuigan, Lorraine Cassidy

This study is a cross-sectional single-center retrospective case series consisting of 16 patients including 12 anti-myelin oligodendrocyte glycoprotein (MOG) positive patients and 4 anti-aquaporin 4 (AQP4) positive patients. Structured clinical exam and multimodal imaging was undertaken sequentially on each. The result indicates that no correlation between initial visual acuity (VA) or retinal nerve fibre layer (RNFL) and final visual outcome is identified. A consensus on treatment of neuromyelitis optica spectrum disorders and anti-MOG positive optic neuropathies has yet to be accepted but initial high dose immunosuppression followed by low dose maintenance therapy is favored. In conclusion, the study has shown the range of clinical characteristics that can be associated with both anti-MOG and anti-AQP4 optic neuropathies. The prompt diagnosis and treatment of these disease is essential to prevent long term ocular sequalae.

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视神经脊髓炎谱系疾病和髓鞘少突胶质细胞糖蛋白抗体阳性视神经炎

该单中心回顾性横断面研究共纳入16例患者，包括12例髓鞘少突胶质细胞糖蛋白(MOG)抗体阳性患者和4例水通道蛋白4(AQP4)抗体阳性患者。依次进行临床组织结构检查和多模态影像学检查。结果表明，初始视力(VA)或视网膜神经纤维层(RNFL)和最终视力之间无明确的相关性。虽然视神经脊髓炎谱系疾病和MOG抗体阳性视神经病变的治疗尚未达成共识，但初始大剂量免疫抑制剂随后低剂量维持治疗仍为首选。总之，该研究总结了一系列与抗MOG和抗AQP4视神经病变相关的临床特征，及时诊断和治疗是预防长期眼后遗症的关键。

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CLINICAL RESEARCH

Relative peripheral refraction and its role in myopia onset in teenage students

Lin-Song Qi, Lu Yao, Xue-Feng Wang, Jin Zhao, Yong Liu, Teng-Yun Wu, Qing-Hong Yang, Chen Zhao, Zhi-Kang Zou

The study was a longitudinal cohort study, which recruited non-myopic junior high school graduates aged 14–16 years from different regions of the country. The study aimed to characterize peripheral refraction and its relationship with incident myopia in teenage Chinese students. Authors found that the incidence of myopia at the 2-year follow-up was 15.29%, and that relative peripheral hyperopia did not predict myopia development in teenage students but was nonetheless higher in students who developed myopia than in those who did not.

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青少年学生相对周边屈光度及其在近视发病中的作用

该研究是一项队列研究，从我国不同地区招募了14-16岁的非近视初中毕业生。研究旨在描述中国青少年学生的周边屈光度及其与偶发性近视的关系。作者发现，在2年的随访中，近视的发生率为15.29%，相对周边远视不能预测青少年学生的近视发展，但发生近视的学生比未发生近视的学生相对周边远视较多见。

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CLINICAL RESEARCH

Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children

Shi-Yin Pan, Yang-Zheng Wang, Jun Li, Xue-Hui Zhang, Jin Wang, Xiu-Ping Zhu, Xiang-Hua Xiao, Jun-Tian Liu

This study investigated the effect of 0.01% atropine sulphate eye gel on myopia progression and axial elongation in a six-month treatment in children. This study comprised an atropine group and a control group. Patients in the atropine group received one drop of 0.01% atropine sulphate eye gel in each eye before bedtime daily for 6mo. The control group comprised matched children without drug intervention during the same period. After 6mo, there was significantly difference in the spherical equivalent progression between the atropine and the control group, with a relative reduction of 55.0% in myopia progression. The increase in axial elongation in the atropine group was significantly less than control group. The results shows atropine sulphate eye gel 0.01% can slow down myopia progression and axial elongation in children with a 6-month treatment.

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0.01%硫酸阿托品眼用凝胶对儿童近视进展的短期影响

该研究调查了为期6个月治疗中0.01%硫酸阿托品眼用凝胶对儿童近视进展和眼轴延长的影响。研究包括阿托品组和对照组。阿托品组患者每天睡前双眼给予0.01%硫酸阿托品凝胶，持续6个月。对照组为同期未进行药物干预的近视儿童。随访6个月，阿托品组与对照组的等效球镜进展有显着差异，近视进展相对减少55.0%，阿托品组眼轴增长率明显小于对照组。表明6个月的0.01%硫酸阿托品眼用凝胶治疗可减缓儿童近视进展和眼轴增长。

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