BASIC RESEARCH

Expression profile analysis to identify potential gene changes induced by dexamethasone in the trabecular meshwork

Miao Wei, Lu-Ming Chen, Ze-Yu Huang, Guo-Wei Zhang, Huai-Jin Guan, Min Ji

This study investigated potential gene changes in trabecular meshwork (TM) induced by dexamethasone (DEX) in steroid-induced glaucoma (SIG). Totally 47 differentially expressed genes (DEGs), including 21 downregulated and 26 upregulated genes were identified. Western blot and quantitative real-time polymerase chain reaction (qPCR) results showed that protein and RNA expression levels of Bradykinin B1 receptor (BDKRB1) were significantly decreased after DEX treatment, while pro-melanin-enriched hormone (PMCH) was not significantly changed. BDKRB1 may be a key gene involved in SIG onset, providing a suitable therapeutic target for improving the prognosis of SIG patients.

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通过表达谱分析识别地塞米松诱导的小梁网潜在基因变化

该研究调查了地塞米松诱导的激素性青光眼小梁网的潜在基因变化。总共调查了47个差异表达基因，包括21个下调基因和26个上调基因。Western blot和qPCR结果显示，地塞米松治疗后，缓激肽B1受体蛋白(BDKRB1)和RNA表达水平显著降低，前黑色素聚集激素(PMCH)无显著变化。BDKRB1可能是激素性青光眼发病的关键基因，为改善激素性青光眼患者的预后提供了合适的治疗靶点。

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CLINICAL RESEARCH

Outcomes and predictors of vitrectomy and silicone oil tamponade in retinal detachments complicated by proliferative vitreoretinopathy

Kenan Sonmez, Hilal Kilinc Hekimsoy

The aim of the study is to evaluate outcomes and determine factors influencing the outcomes of vitreoretinal surgery with silicone oil (SO) endotamponade for the management of rhegmatogenous retinal detachment (RRD) complicated by advanced proliferative vitreoretinopathy (PVR). Although encouraging anatomical and functional outcomes are achieved after vitrectomy and SO tamponade in eyes with RRD complicated by PVR, an increase in aqueous flare or cells at the first week follow-up is most likely to result in postoperative late complications. Primary vitrectomy, PVR associated with minimal posterior pole extension and absent to mild postoperative aqueous inflammation are associated with improved post-operative final visual acuity.

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玻璃体切除术联合硅油填充治疗视网膜脱离合并增殖性玻璃体视网膜病变的预后和预测因素

该研究旨在评价玻璃体视网膜手术联合硅油(SO)填充治疗孔源性视网膜脱离(RRD)合并增殖性玻璃体视网膜病变(PVR)的疗效及影响因素。尽管于玻璃体切除联合和SO填充术治疗RRD合并PVR在解剖学和功能上取得了令人鼓舞的结果，但术后一周房水闪辉或细胞的增加极可能导致术后晚期并发症。一期玻璃体切除、PVR波及后极部范围小以及术后无或者轻度房水炎症与术后最终视力的改善有关。

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CLINICAL RESEARCH

Changes in axial length after vitrectomy for rhegmatogenous retinal detachment combined with choroidal detachment

Ji-Peng Li, Jun Xu, Meng Zhao

This study aims to evaluate the postoperative axial length (AL) changes in rhegmatogenous retinal detachment combined with choroidal detachment (RRD-CD) patients. The potential factors influencing AL after the pars plana vitrectomy surgery were further investigated. The results show that RRD-CD patients are very likely to have a postoperative elongation of AL. AL elongation after PPV was 1.01 mm in the RRD-CD group, which was greater than in RRD only group (0.15 mm). AL increased 0.06 mm per 1 mm Hg intraocular pressure changes in the RRD-CD group. The primary intraoclular lens implantation using presurgery AL data may cause a significant refractive error in RRD-CD patients who underwent pars plana vitrectomy.

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孔源性视网膜脱离合并脉络膜脱离患者行玻璃体切除术后眼轴长度的变化

该研究评估了孔源性视网膜脱离合并脉络膜脱离患者术后眼轴长度的变化以及影响术后眼轴长度的潜在因素。其结果表明患者术后很可能出现眼轴增长。术后合并脉络膜脱离的患者眼轴增长1.01 mm，明显高于单纯孔源性视网膜脱离患者(0.15 mm)。合并脉络膜脱离的患者眼压每改变1 mm Hg, 眼轴增加0.06 mm。因此一期进行人工晶体植入时如果采用玻切术前的眼轴长度数据则可能会导致较大的屈光偏差。

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INVESTIGATION

Elementary school comprehensive intervention and myopia development: The Wenzhou Epidemiology of Refraction Error Study

Dan-Dan Jiang, Jie Chen, Frank Thorn, Guang-Yun Mao, Chun-Chun Li, Zhong Lin, Balamurali Vasudevan, Xiao-Qiong Huang, Yan-Yan Chen

This study aimed to evaluate the effects of comprehensive intervention on the prevention of myopia in elementary school children. There were 1524 participating elementary students (730 girls, 46.2%) in grades 1 to 3 from three campuses of one school, aged 7.3±0.9y, who were examined twice every year for a 2.5y follow up period. Intervention methods included education intervention and behaviour intervention, e.g., ocular health-related knowledge education for students, parents and teachers, outdoor activities, standardized classroom desks and chairs. It turns out the comprehensive intervention program at elementary school has a significant alleviating effect on myopia progression for children during the 2.5y follow-up, especially for those non-myopia at baseline.

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小学阶段综合干预与近视发展:温州市屈光不正流行病学研究

该研究旨在评价综合干预措施对小学生近视预防的效果。研究对象为同一所学校三个校区1-3年级1524名小学生(女生730名，占46.2%)，年龄7.3±0.9岁，每年检查2次，随访2.5年。干预方法包括教育干预和行为干预，如对学生、家长和教师进行眼部健康相关知识教育，开展户外活动，标准化的课桌椅等。结果表明，随访期间小学阶段综合干预方案对儿童的近视有显著的延缓作用，尤其是对纳入时尚未发生近视的儿童。

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