BASIC RESEARCH

Corneal histomorphology and electron microscopic observation of R124L mutated corneal dystrophy in a relapsed pedigree

Meng-Jun Fu, Jing Zhao, Shan Duan, Hao-Run Zhang, Jing-Jing Zhao, Li Zeng, Rui Wang, Xing-Tao Zhou

This study investigated the histological characteristics and ultrastructure of recurrent Chinese R124L mutated corneal dystrophy after keratoplasty. The subjects were enrolled from a Chinese family of corneal dystrophy with R124L heterozygous gene mutation and with a history of consanguineous marriage. Normal corneal samples were used as controls. The results showed in the Chinese family of recurrent corneal dystrophy with R124L gene mutation, the corneal epithelia of the recurrent cases are rougher, and the corneal depositions are extracellular amyloid fibrin.

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R124L突变的复发家族性角膜营养不良的角膜组织形态学和电镜观察

该研究探讨了R124L突变患者角膜移植术后的复发性角膜营养不良的组织学特征和超微结构。受试者来自角膜营养不良中国家系，携带R124L杂合子基因突变，有近亲婚姻史。正常角膜标本作为对照组。结果表明在R124L基因突变的复发性角膜营养不良家系中，复发病例的角膜上皮较粗糙，角膜沉积物为细胞外淀粉样纤维蛋白。

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CLINICAL RESEARCH

Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial

Javaria Bukhari, Shi-Fei Wei, Shi-Ming Li, Wen-Zai An, Jia-Ling Du, Xin-Tong Liang, Jia-He Gan, Jia-Xin Tian, Wei-Ling Bai, Zhi-Ning Cai, Lei Yin, Ning-Li Wang

This placebo-controlled, double-masked, randomized trial of one year study aims to assess the effect of 0.01% atropine eye drops on intraocular pressure (IOP) in myopic children. A total of 220 children aged 6 to 12y with myopia were recruited into the study, with equal randomization to the 0.01% atropine and the placebo groups. At one year follow-up, the mean change of IOP was 0.16 mm Hg for the 0.01% atropine group and -0.11 mm Hg for placebo group (P=0.525) after adjusting for central corneal thickness. It is concluded that 0.01% of atropine eye drops did not induce a rise in IOP in this study, and 0.01% of atropine eye drops are relatively safe to use in myopic children. In the future, further studies can conduct more details with a larger sample size and more years of follow-up to authenticate the findings.

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0.01%阿托品滴眼液对学龄儿童眼压的影响：一项随机临床试验

研究者通过为期一年的安慰剂对照、双盲、随机试验评估0.01%阿托品滴眼液对近视儿童眼压的影响。共有220名6至12岁的近视儿童被纳入该研究，随机分为0.01%阿托品组和安慰剂组。在一年的随访中，校正角膜中央厚度后，0.01%阿托品组的平均眼压变化为0.16 mm Hg，安慰剂组的平均眼压变化为-0.11 mm Hg (P=0.525)。表明0.01%的阿托品滴眼液并不会引起眼压升高，0.01%的阿托品滴眼剂用于近视儿童是相对安全的。今后，可通过扩大样本量和增加随访年限来进一步验证研究结果。

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CLINICAL RESEARCH

Reproducibility of macular perfusion parameters in non-proliferative diabetic retinopathy patients by two different OCTA sweep modes

Shen Qu, Ao Rong, Yun-Li Niu, Xin Liu, Yu-Shan Zhang, Chun-Yu Liu, Yan-Long Bi

The study was aimed to assess the reproducibility of macular perfusion parameters in non-proliferative diabetic retinopathy (NPDR) patients measured by different examiners and two different sweep modes of optical coherence tomography angiography (OCTA). Cirrus OCTA can measure macular perfusion parameters in NPDR patients with excellent reproducibility. The measurements of foveal avascular zone and vessel density in the superficial retinal layer determined by Angiography 3×3 and 6×6 mm² sweep mode are highly consistent and both sweep modes are suitable for macular perfusion parameters measurement.

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两种OCTA扫描模式测量非增殖性糖尿病视网膜病变患者黄斑区灌注参数的重复性

该研究旨在评估通过不同的检查者和两种不同扫描模式的光学相干断层扫描血管造影(OCTA)测量非增殖性糖尿病视网膜病变(NPDR)患者黄斑区灌注参数的重复性。Cirrus OCTA可以测量NPDR患者的黄斑区灌注参数，重复性好。血管造影3×3和6×6 mm²扫描模式对视网膜中心凹浅层无血管区和血管密度的测量具有高度一致性，两种扫描模式均适用于黄斑区灌注参数的测量。

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BRIEF REPORT

COVID-19 infection with keratitis as the first clinical manifestation

Dong-Mei Zuo, Lin-Ping Xue, Heng Fan, Sheng-Li Yang, Liang-Chang Li, Ji-Hong Luo, Shuo Zang, Jun Xiao

This study aimed to report a case which COVID-19 infection with keratitis as the first clinical manifestation that occurred 3 days earlier than the common COVID-19 symptoms. A 35-year-old male suddenly suffered pain, photophobia, and tears in his right eye for one day without systemic COVID-19 symptoms. Patient was diagnosed with keratitis, ganciclovir eye drop was initiated. After that, the corneal scraping test for COVID-19 was positive. The chest CT images were abnormal confirming the diagnosis of COVID-19 infection. It turns out the earlier a COVID-19 symptom is identified, the earlier can a patient be directed to stay at home, and significantly fewer people would be infected.

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以角膜炎为首发症状的COVID-19感染

该研究报告了1例以角膜炎为首发临床表现的COVID-19感染，比COVID-19常见症状早出现3天。该病例为一名35岁男性，患者以右眼突然疼痛、畏光、流泪一天就诊，无COVID-19感染的其它全身症状。患者被诊断为角膜炎，并给予更昔洛韦滴眼液治疗。角膜刮片试验COVID-19阳性，结合胸部CT表现异常，确诊为COVID-19感染。COVID-19感染发现得越早，患者越早被及时被隔离，感染传播的人数将会大幅度减少。

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