BASIC RESEARCH

Anti-inflammatory effects of α-humulene and β-caryophyllene on pterygium fibroblasts

Magda Massae Hata Viveiros, Márcia Guimarães Silva, José Galberto Martins da Costa, Anselmo Gomes de Oliveira, Carolina Rubio, Carlos Roberto Padovani, Cláudia Aparecida Rainho, Silvana Artioli Schellini

Brazil is a country of great biodiversity and with a high prevalence of pterygium, a frequent lesion in the tropical and equatorial regions of our planet. The aim of the study is to investigate the anti-inflammatory effects of the sesquiterpenes α-humulene and β-caryophyllene on pterygium fibroblasts. The exposure to 25 μmol/L of β-caryophyllene significantly reduce the production of IL-6 by pterygium fibroblasts after 48h. The levels of IL-1β, IL-8, IL-10 and TNF-α were very low and had no statistically significant variations after exposure to α-humulene, β-caryophyllene, or both compounds together. This study shows that this herbal medicine can interfere on interleukins production.

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α-葎草烯和β-石竹烯对翼状胬肉成纤维细胞的抗炎作用

巴西是一个生物多样性丰富的国家，翼状胬肉的发病率很高，翼状胬肉是地球上热带和赤道地区的一种常见疾病。该研究旨在探讨α-葎草烯和β-石竹烯对翼状胬肉成纤维细胞的抗炎作用。β-石竹烯25 μmol/L作用48小时后，翼状胬肉成纤维细胞IL-6水平显著降低，而IL-1β、IL-8、IL-10和TNF-α在α-葎草烯、β-石竹烯或两者联合作用后均呈极低水平，差异无统计学意义。该研究表明草药可以干扰白介素的产生。

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REVIEW ARTICLE

Nanopore techniques as a potent tool in the diagnosis and treatment of endophthalmitis: a literature review

Zi-Yue Li, Ke-Yi-Zhi Xu, Wei Jin

Endophthalmitis is a serious ophthalmic disease characterized by changes in the eye’s posterior segment, such as hypopyon and intraocular inflammation, vitritis being a hallmark. This article introduced the current research status of molecular sequencing in endophthalmitis and discussed exciting development in sequencing technology. Despite the challenges, we believe that nanopore-targeted sequencing has greatly contributed to the progress of genomics in the field of endophthalmitis and that this is the way forward for research. It is likely that we will see an increasing number of clinical trials testing combinations of technologies, probing potential mechanisms, and collaborating to drive progression in the diagnosis and treatment of endophthalmitis.

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纳米孔技术用于诊断和治疗眼内炎的研究进展

眼内炎是一种严重的眼病，其特征是眼后节的变化，如前房积脓和眼内炎症，其中玻璃体炎是其标志。该文介绍了分子测序技术在眼内炎中的研究现状，并对测序技术的发展进行了展望。尽管存在挑战，作者相信纳米孔靶向测序将对眼内炎领域的基因组学进展做出巨大贡献，这也是研究的方向。我们很可能会看到越来越多的临床试验，测试技术的组合，探索其潜在的机制，并协同推动眼内炎的诊断和治疗进展。

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CLINICAL RESEARCH

A simple technique for suprachoroidal space injection of triamcinolone acetonide in treatment of macular edema

Dan-Dan Zhang, Dan-Yang Che, Dong-Qing Zhu

This study aims to introduce a simple resistance controlled suprachoroidal space injection technique using a disposable 30-gauge needle connected to a 1 mL syringe and evaluate the effectiveness and applicability of this technique in the treatment of macular edema. A total of 20 patients with various types of macular edema were included and the main outcome measures were anterior segment spectral-domain optical coherence tomography measurements post-operation immediately and central subfield thickness, best-corrected visual acuity, and intraocular pressure measurements at 3mo post-operation. The results show that this easy and minimally invasive technique of is effective and applicable for macular edema and could be explored as a suitable alternative to intravitreal injection.

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脉络膜上腔注射曲安奈德——一种治疗黄斑水肿的简单方法

该研究介绍了一种简单的依靠注射阻力控制的脉络膜上腔注射技术，该技术使用一次性30G针头连接到1mL注射器，并评估该技术在治疗黄斑水肿中的有效性和适用性。共纳入20名不同类型黄斑水肿的患者，观察术后眼前节SD-OCT和术后3个月黄斑区视网膜厚度、最佳矫正视力和眼内压。结果表明，这种简单且微创的技术对黄斑水肿有效且适用，可作为玻璃体内注射的适当替代方案。

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