Basic Research    

Electroacupuncture alleviates ciliary muscle cell apoptosis in lens-induced myopic guinea pigs through inhibiting the mitochondrial signaling pathway

Zhao-Hui Yang, Jia-Wen Hao, Jin-Peng Liu, Bo Bao, Tu-Ling Li, Qiu-Xin Wu, Ming-Guang He, Hong-Sheng Bi, Da-Dong Guo

This study aims to explore the role of the mitochondrial apoptosis pathway mediated by dynamin-related protein 1 (DRP1) in the ciliary muscle of guinea pigs with lens-induced myopia, investigated the effect of electroacupuncture on the development of myopia, clarified whether electroacupuncture can improve the function of ciliary muscles to inhibit the development of myopia by affecting the mitochondrial apoptotic signaling pathway. The findings show that the mitochondrial apoptosis pathway of the ciliary muscle is activated in experimental myopia and electroacupuncture intervention can reduce cell apoptosis and restore the physiological function of the ciliary muscle, providing new insights for the treatment of myopia with electroacupuncture.

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电针通过抑制线粒体信号通路减轻透镜诱导型近视豚鼠的睫状肌细胞凋亡

该研究旨在探讨动力蛋白相关蛋白（DRP1）介导的线粒体凋亡通路在透镜诱导型近视豚鼠的睫状肌中的作用，研究了电针对近视发展的影响，阐明了电针是否可以通过影响线粒体凋亡信号通路来改善睫状肌抑制近视发展的功能。研究结果表明，实验性近视睫状肌线粒体凋亡通路被激活，电针干预可减少细胞凋亡，恢复睫状肌的生理功能，为电针治疗近视提供了新的思路。

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    Clinical Research    

Agreements’ profile of Scheimpflug-based optical biometer with gold standard partial coherence interferometry

Sara Sardari, Akbar Fotouhi, Ebrahim Jafarzadehpur, Mehdi Khabazkhoob

Ocular biometric measurements are of great importance in ophthalmic studies as well as clinical practice. These measurements are used for the intraocular lens (IOL) power calculation before cataract surgery, screening of refractive surgery candidates, diagnosing and monitoring primary angle-closure glaucoma, and monitoring the progression of ametropia. To determine the agreement of ocular biometric indices including axial length, keratometric readings, anterior chamber depth, and horizontal corneal diameter between the Pentacam AXL and IOL Master 500. In conclusion, the Pentacam AXL has excellent agreement with the gold standard, IOL Master 500 in measuring axial length. In eyes with cataracts, the difference between the two devices is more scattered. With the increasing of axial length, the difference between the two devices increased, which should be considered when using Pentacam AXL.

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基于Scheimpflug的光学生物测量仪与金标准部分相干干涉测量仪的一致性研究

眼生物测量在眼科研究和临床实践中具有重要意义。这些测量用于白内障术前人工晶体(IOL)的度数计算，屈光手术的筛选，原发性闭角型青光眼的诊断和监测，以及屈光不正的进展监测。该研究比较了Pentacam AXL与IOL Master 500测量眼轴长度、角膜曲率、前房深度、角膜水平直径等眼部生物学参数的一致性。结论显示，Pentacam AXL与金标准IOL Master 500测量眼轴具有良好的一致性。在白内障患者中，两种设备的差异更分散。随着眼轴长度的增加，两种仪器之间的差异增大，在使用Pentacam AXL时应考虑到这一点。

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    Clinical Research    

Optical coherence tomography angiography for macular microvessels in ischemic branch retinal vein occlusion treated with conbercept: predictive factors for the prognosis

Li Tang, Guang-Li Sun, Yue Zhao, Ting-Ting Yang, Jin Yao

This study evaluate the predicative factors of visual prognosis using optical coherence tomography angiography (OCTA) in ischemic branch retinal vein occlusion (BRVO) patients with macular edema (ME) after anti-vascular endothelial growth factor (VEGF) treatment. Totally 60 patients (60 eyes) with a definite diagnosis of ischemic BRVO with ME were studied. The results showed all patients showed significant improvement in best-corrected visual acuity (BCVA). The mean central macular thickness (CMT) significantly decreased. Both the foveal avascular zone (FAZ) area and A-circularity index (AI) at 6mo were significantly higher than those at the baseline. Using OCTA to observe macular ischemia and quantify parameters can better predict the final visual prognosis of patients before treatment. The changes in FAZ parameters may influence the visual prognosis and injection times.

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康柏西普治疗缺血性视网膜分支静脉阻塞黄斑微血管的光学相干断层扫描血管成像:预后的预测因素

该研究采用光学相干断层扫描血管成像评估缺血型视网膜分支静脉阻塞合并黄斑水肿患者抗血管内皮生长因子治疗后视力预后的预测因素。研究共纳入缺血型视网膜分支静脉阻塞伴黄斑水肿患者60例(60只眼)。结果表明所有患者最佳矫正视力均显著提高。平均黄斑中心凹厚度显著降低。术后六个月中心凹无血管区面积和形态指数均较基线时显著增加。在治疗前使用相干光断层扫描血管成像观察黄斑缺血并量化参数可以更好地预测患者的最终视力预后。中心凹无血管区参数的变化可能会影响视力预后和注射次数。

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