Highlight Articles in Int J Ophthalmol Vol.15 No.5 2022
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Highlight Articles in Int J Ophthalmol Vol.15 No.5 2022



Yes-associated protein promotes endothelial-to-mesenchymal transition of endothelial cells in choroidal neovascularization fibrosis

Rong Zou, Yi-Fan Feng, Ya-Hui Xu, Min-Qian Shen, Xi Zhang, Yuan-Zhi Yuan


This study aimed to clarify the role of Yes-associated protein (YAP) in hypoxia-inducible factor-1α (HIF-1α)-induced endothelial-to-mesenchymal transition (EndMT). It turns that silencing of YAP expression significantly prevented the fibrotic process in a laser-induced choroidal neovascularization (CNV) mouse model, which suggests that YAP may be an attractive target for treatment of age-related macular degeneration (AMD) with the advantage of controlling both CNV and subretinal fibrosis. These findings reveal a critical role of the HIF-1α/YAP signaling axis in EndMT and provide a new therapeutic target for treatment of subretinal fibrosis in AMD.






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Neuroretinal dysfunction in patients affected by neurofibromatosis type 1

Antonietta Moramarco, Luca Lucchino, Fabiana Mallone, Michela Marcelli, Ludovico Alisi, Vincenzo Roberti, Sandra Giustini, Alessandro Lambiase, Marcella Nebbioso


This study aims to examine neuroretinal function by using the multifocal electroretinography (mfERG) test in patients with neurofibromatosis type 1 (NF1) without optic pathway gliomas (OPGs). This study was conducted on 35 patients (35 eyes) with NF1 and 30 healthy subjects (30 eyes) for the control group. The mfERG evaluation in patients affected by NF1 showed a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees attributable to retinal function impairment. This abnormality is subclinical as all patients, did not have a reduced visual acuity nor had any underlying disease that could have affected the outcome of the research. These observations suggest a possible use of mfERG as subclinical retinal damage indicator with a potential utility in clinical practice for the follow-up of NF1 patients.






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Inflammation and dry eye disease-where are we?

Srinivas K Rao, Rishi Mohan, Nikhil Gokhale, Himanshu Matalia, Paras Mehta


The presence of inflammation in dry eye disease (DED) results in increased patient symptomatology, ocular surface damage and worsening tear dysfunction. It also affects the health of meibomian glands and their secretions which further aggravates ocular surface disease. This article reviews current knowledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED, inflammation and meibomian gland dysfunction (MGD).





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Published date:2022-04-27Click:

Editors-in-Chief: Yan-Nian Hui and Peter Wiedemann

Established in April, 2008

ISSN 2222-3959 print

ISSN 2227-4898 online

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