Highlight Articles in Int J Ophthalmol Vol.15 No.8 2022
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Highlight Articles in Int J Ophthalmol Vol.15 No.8 2022



Expression profile analysis to identify potential gene changes induced by dexamethasone in the trabecular meshwork

Miao Wei, Lu-Ming Chen, Ze-Yu Huang, Guo-Wei Zhang, Huai-Jin Guan, Min Ji


This study investigated potential gene changes in trabecular meshwork (TM) induced by dexamethasone (DEX) in steroid-induced glaucoma (SIG). Totally 47 differentially expressed genes (DEGs), including 21 downregulated and 26 upregulated genes were identified. Western blot and quantitative real-time polymerase chain reaction (qPCR) results showed that protein and RNA expression levels of Bradykinin B1 receptor (BDKRB1) were significantly decreased after DEX treatment, while pro-melanin-enriched hormone (PMCH) was not significantly changed. BDKRB1 may be a key gene involved in SIG onset, providing a suitable therapeutic target for improving the prognosis of SIG patients.





该研究调查了地塞米松诱导的激素性青光眼小梁网的潜在基因变化。总共调查了47个差异表达基因,包括21个下调基因和26个上调基因。Western blotqPCR结果显示,地塞米松治疗后,缓激肽B1受体蛋白(BDKRB1)RNA表达水平显著降低,前黑色素聚集激素(PMCH)无显著变化。BDKRB1可能是激素性青光眼发病的关键基因,为改善激素性青光眼患者的预后提供了合适的治疗靶点。

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Outcomes and predictors of vitrectomy and silicone oil tamponade in retinal detachments complicated by proliferative vitreoretinopathy

Kenan Sonmez, Hilal Kilinc Hekimsoy


The aim of the study is to evaluate outcomes and determine factors influencing the outcomes of vitreoretinal surgery with silicone oil (SO) endotamponade for the management of rhegmatogenous retinal detachment (RRD) complicated by advanced proliferative vitreoretinopathy (PVR). Although encouraging anatomical and functional outcomes are achieved after vitrectomy and SO tamponade in eyes with RRD complicated by PVR, an increase in aqueous flare or cells at the first week follow-up is most likely to result in postoperative late complications. Primary vitrectomy, PVR associated with minimal posterior pole extension and absent to mild postoperative aqueous inflammation are associated with improved post-operative final visual acuity.





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Changes in axial length after vitrectomy for rhegmatogenous retinal detachment combined with choroidal detachment

Ji-Peng Li, Jun Xu, Meng Zhao


This study aims to evaluate the postoperative axial length (AL) changes in rhegmatogenous retinal detachment combined with choroidal detachment (RRD-CD) patients. The potential factors influencing AL after the pars plana vitrectomy surgery were further investigated. The results show that RRD-CD patients are very likely to have a postoperative elongation of AL. AL elongation after PPV was 1.01 mm in the RRD-CD group, which was greater than in RRD only group (0.15 mm). AL increased 0.06 mm per 1 mm Hg intraocular pressure changes in the RRD-CD group. The primary intraoclular lens implantation using presurgery AL data may cause a significant refractive error in RRD-CD patients who underwent pars plana vitrectomy.





该研究评估了孔源性视网膜脱离合并脉络膜脱离患者术后眼轴长度的变化以及影响术后眼轴长度的潜在因素。其结果表明患者术后很可能出现眼轴增长。术后合并脉络膜脱离的患者眼轴增长1.01 mm,明显高于单纯孔源性视网膜脱离患者(0.15 mm)。合并脉络膜脱离的患者眼压每改变1 mm Hg, 眼轴增加0.06 mm。因此一期进行人工晶体植入时如果采用玻切术前的眼轴长度数据则可能会导致较大的屈光偏差。

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Elementary school comprehensive intervention and myopia development: The Wenzhou Epidemiology of Refraction Error Study

Dan-Dan Jiang, Jie Chen, Frank Thorn, Guang-Yun Mao, Chun-Chun Li, Zhong Lin, Balamurali Vasudevan, Xiao-Qiong Huang, Yan-Yan Chen


This study aimed to evaluate the effects of comprehensive intervention on the prevention of myopia in elementary school children. There were 1524 participating elementary students (730 girls, 46.2%) in grades 1 to 3 from three campuses of one school, aged 7.3±0.9y, who were examined twice every year for a 2.5y follow up period. Intervention methods included education intervention and behaviour intervention, e.g., ocular health-related knowledge education for students, parents and teachers, outdoor activities, standardized classroom desks and chairs. It turns out the comprehensive intervention program at elementary school has a significant alleviating effect on myopia progression for children during the 2.5y follow-up, especially for those non-myopia at baseline.






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Published date:2022-07-29Click:

Editors-in-Chief: Yan-Nian Hui and Peter Wiedemann

Established in April, 2008

ISSN 2222-3959 print

ISSN 2227-4898 online

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