Highlight Articles in Int J Ophthalmol Vol.15 No.12 2022
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Highlight Articles in Int J Ophthalmol Vol.15 No.12 2022



Anti-inflammatory effects of α-humulene and β-caryophyllene on pterygium fibroblasts

Magda Massae Hata Viveiros, Márcia Guimarães Silva, José Galberto Martins da Costa, Anselmo Gomes de Oliveira, Carolina Rubio, Carlos Roberto Padovani, Cláudia Aparecida Rainho, Silvana Artioli Schellini


Brazil is a country of great biodiversity and with a high prevalence of pterygium, a frequent lesion in the tropical and equatorial regions of our planet. The aim of the study is to investigate the anti-inflammatory effects of the sesquiterpenes α-humulene and β-caryophyllene on pterygium fibroblasts. The exposure to 25 μmol/L of β-caryophyllene significantly reduce the production of IL-6 by pterygium fibroblasts after 48h. The levels of IL-1β, IL-8, IL-10 and TNF-α were very low and had no statistically significant variations after exposure to α-humulene, β-caryophyllene, or both compounds together. This study shows that this herbal medicine can interfere on interleukins production.





巴西是一个生物多样性丰富的国家,翼状胬肉的发病率很高,翼状胬肉是地球上热带和赤道地区的一种常见疾病。该研究旨在探讨α-葎草烯和β-石竹烯对翼状胬肉成纤维细胞的抗炎作用。β-石竹烯25 μmol/L作用48小时后,翼状胬肉成纤维细胞IL-6水平显著降低,而IL-1βIL-8IL-10TNF-α在α-葎草烯、β-石竹烯或两者联合作用后均呈极低水平,差异无统计学意义。该研究表明草药可以干扰白介素的产生。

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Nanopore techniques as a potent tool in the diagnosis and treatment of endophthalmitis: a literature review

Zi-Yue Li, Ke-Yi-Zhi Xu, Wei Jin


Endophthalmitis is a serious ophthalmic disease characterized by changes in the eye’s posterior segment, such as hypopyon and intraocular inflammation, vitritis being a hallmark. This article introduced the current research status of molecular sequencing in endophthalmitis and discussed exciting development in sequencing technology. Despite the challenges, we believe that nanopore-targeted sequencing has greatly contributed to the progress of genomics in the field of endophthalmitis and that this is the way forward for research. It is likely that we will see an increasing number of clinical trials testing combinations of technologies, probing potential mechanisms, and collaborating to drive progression in the diagnosis and treatment of endophthalmitis.






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A simple technique for suprachoroidal space injection of triamcinolone acetonide in treatment of macular edema

Dan-Dan Zhang, Dan-Yang Che, Dong-Qing Zhu


This study aims to introduce a simple resistance controlled suprachoroidal space injection technique using a disposable 30-gauge needle connected to a 1 mL syringe and evaluate the effectiveness and applicability of this technique in the treatment of macular edema. A total of 20 patients with various types of macular edema were included and the main outcome measures were anterior segment spectral-domain optical coherence tomography measurements post-operation immediately and central subfield thickness, best-corrected visual acuity, and intraocular pressure measurements at 3mo post-operation. The results show that this easy and minimally invasive technique of is effective and applicable for macular edema and could be explored as a suitable alternative to intravitreal injection.






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Published date:2022-11-23Click:

Editors-in-Chief: Yan-Nian Hui and Peter Wiedemann

Established in April, 2008

ISSN 2222-3959 print

ISSN 2227-4898 online

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